The recombinant production process offers the possibility of facile inclusion of various bioactivities in fusion with the silk proteins. Several bioactive molecules, e.g. cell adhesion sites, antimicrobial peptides, affinity domains, enzymes and growth factors, have been connected to Spiber® through genetic modification.

In theory, any other gene sequence can be added to give the silk materials new functionality. Because the formulations into silk materials is done by self-assembly under physiological conditions, the fold of the added protein domains is preserved, yielding bioactive Spiber® silk materials.

Spiber® integrates in biological systems with good biocompatibility. The biomaterial is non-immunogenic and biodegradable.

Various applications:


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Cell adhesion motifs

Antimicrobial peptides

Affinity domains

Formulation of Spiber® silk materials

After expression and purification under native conditions, the spider silk proteins can self-assemble into several formats.

Fiber bundles

Fiber bundles support directional cell growth along the fibers.


Films are free-standing, thin, transparent and lightweight materials.


Foam is a soft, flexible three dimensional scaffold.


Coatings provide immobilization of functional units onto various base materials.