The same approach as spiders use to preserve the solubility of a protein with a high tendency to form solid fibers can be applied to other proteins that are prone to aggregate.
Spiber Technologies proprietary SolvNT® technology is developed for recombinant production of protein drugs and drug targets. The unsurpassed properties of nature's own protein solubility tag - the spidroin N-Terminal domain - are harnessed by joining it to target proteins. The SolvNT® technology enables production of difficult to produce target proteins, such as membrane peptides and proteins. SolvNT® also works as a tool for keeping various kinds of proteins soluble at high concentrations.
Spiber Technologies provides evaluation service of your protein of interest together with our SolvNT® technology.
(2017) Nature communications 8:15504