The same approach as spiders use to preserve the solubility of a protein with a high tendency to form solid fibers can be applied to other proteins that are prone to aggregate.
Spiber Technologies proprietary SolvNT® technology is developed for recombinant production of protein drugs and drug targets. The unsurpassed properties of nature's own protein solubility tag - the spidroin N-Terminal domain - are harnessed by joining it to target proteins. The SolvNT® technology enables the production of difficult to produce target proteins, such as membrane peptides and intrinsically disordered proteins. SolvNT® also works as a tool for keeping various kinds of proteins soluble at high concentrations.
Spiber Technologies provides evaluation service of your protein of interest together with our SolvNT® technology.
Efficient protein production inspired by how spiders make silk
Kronqvist, N., Sarr, M., Lindqvist, A., Nordling, K., Otikovs, M., Venturi, L., Pioselli, B., Purhonen, P., Landreh, M., Biverstål, H., Toleikis, Z., Sjöberg, L., Robinson, C.V., Pelizzi, N., Jörnvall, H., Hebert, H., Jaudzems, K., Curstedt, T., Rising, A., Johansson, J.
(2017) Nature Communications, 8:15504